Research
We are currently performing research on a variety of projects for improved understanding of coccidioidomycosis, cryptococcosis, and aspergillosis using existing patient data. Please see below for a list of publications on fungal diseases of dogs and cats from our team.
Sapienza HP, Westropp JL, Murphy B, Canete-Gibas C, Wiederhold N, Dear JD. Disseminated Talaromyces boninensis and T. pigmentosus infections in 2 dogs. Med Mycol Case Rep. 2025;49:100705.
Chan JC, Dear JD, Palm C, Reagan K. Incidence of acute kidney injury in dogs with systemic mycotic infections treated with amphotericin B (1996-2020). Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine. 2023;37(3):1030-7.
Ringhofer JD, EM HI, Michalak SR, Wiederhold N, Canete-Gibas C, Dear JD. Disseminated Scytalidium philadelphianum infection in a Belgian Malinois. Med Mycol Case Rep. 2025;47:100692.
Bromel C, Sykes JE. Epidemiology, diagnosis, and treatment of blastomycosis in dogs and cats. Clin Tech Small Anim Pract 2005;20:233-9.
Bromel C, Sykes JE. Histoplasmosis in dogs and cats. Clin Tech Small Anim Pract 2005;20:227-32.
Davidson AP, Shubitz LF, Alcott CJ, Sykes JE. Selected clinical features of coccidioidomycosis in dogs. Med Mycol 2019;57:S67-S75.
Dear JD, Reagan KL, Hulsebosch SE, et al. Disseminated Rasamsonia argillacea species complex infections in 8 dogs. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2021.
Dear JD, Sykes JE, Bannasch DL. Quality of DNA extracted from formalin-fixed, paraffin-embedded canine tissues. J Vet Diagn Invest 2020;32:556-9.
Firacative C, Roe CC, Malik R, et al. MLST and whole-genome-based population analysis of Cryptococcus gattii VGIII links clinical, veterinary and environmental strains, and reveals divergent serotype specific sub-populations and distant ancestors. PLoS Negl Trop Dis 2016;10:e0004861
Garcia RS, Wheat LJ, Cook AK, et al. Sensitivity and specificity of a blood and urine galactomannan antigen assay for diagnosis of systemic aspergillosis in dogs. J Vet Intern Med 2012;26, 911-919.
Grayzel SE, Martinez-Lopez B, Sykes JE. Risk factors and spatial distribution of canine coccidioidomycosis in California, 2005-2013. Transbound Emerg Dis 2017;64:1110-9.
Grayzel SE, Thompson GR, Martinez-Lopez B, Dechant JE, McHardy I, Sykes JE. Coccidioidomycosis in llamas and alpacas diagnosed at the University of California, Davis (1990-2016). Med Mycol 2020.
Groff JM, Mok MY, Kubiski S, et al. Phaeohyphomycosis due to Veronaea botryosa in cultured white sturgeon (Acipenser transmontasus Richardson) from California USA during 2005 to 2015. J Fish Dis 2021;44:793-801.
Reagan KL, Dear JD, Kass PH, Sykes JE. Risk factors for Candida urinary tract infections in dogs and cats. J Vet Intern Med 2019;33:648-53.
Reagan KL, McHardy I, Thompson GR, 3rd, Sykes JE. Evaluation of the clinical performance of 2 point-of-care cryptococcal antigen tests in dogs and cats. J Vet Intern Med 2019;33:2082-9.
Reagan KL, McHardy I, Thompson GR, 3rd, Sykes JE. Clinical performance of a point-of-care Coccidioides antibody test in dogs. J Vet Intern Med 2021;35:965-9.
Reagan KL, Wheat LJ, Sykes JE. Effect of an oral probiotic nutraceutical containing Aspergillus-derived ingredients on a serum and urine galactomannan antigen assay in dogs. Vet J 2020;265:105551.
Schultz RM, Johnson EG, Wisner ER, Brown NA, Byrne BA, Sykes JE. Clinicopathologic and diagnostic imaging characteristics of systemic aspergillosis in 30 dogs. J Vet Intern Med 2008;22:851-9.
Smith KM, Strom AR, Gilmour MA, et al. Utility of antigen testing for the diagnosis of ocular histoplasmosis in four cats: a case series and literature review. J Feline Med Surg 2017;19:1110-8.
Sykes JE, Hodge G, Singapuri A, Yang ML, Gelli A, Thompson GR, 3rd. In vivo development of fluconazole resistance in serial Cryptococcus gattii isolates from a cat. Med Mycol 2017;55:396-401.
Sykes JE, Sturges BK, Cannon MS, et al. Clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from California. J Vet Intern Med 2010;24:1427-38.
Thompson GR, 3rd, Albert N, Hodge G, et al. Phenotypic differences of Cryptococcus molecular types and their implications for virulence in a Drosophila model of infection. Infect Immun 2014;82:3058-65.
Trivedi SR, Sykes JE, Cannon MS, et al. Clinical features and epidemiology of cryptococcosis in cats and dogs in California: 93 cases (1988-2010). J Am Vet Med Assoc 2011;239:357-69.
Vishkautsan P, Papich MG, Thompson GR, et al. Pharmacokinetics of voriconazole after intravenous and oral administration to healthy cats. Am J Vet Res 2016;77: 931-939.
Vu K, Thompson GR, 3rd, Roe CC, et al. Flucytosine resistance in Cryptococcus gattii is indirectly mediated by the FCY2-FCY1-FUR1 pathway. Med Mycol 2018;56:857-67.
Woerde DJ, Wittenburg LA, Dear JD. Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration. Journal of Veterinary Internal Medicine 2022.